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From this synthesis, we propose restoration of copper balance using copper delivery agents in combination with chaperones/chaperone mimetics, perhaps in conjunction with the neuroprotective amino acid serine, as a promising strategy in the treatment of this incurable disease

It appears that diverse mechanisms (i.e., chromatin modification, RBPs, and PTMs) are involved in stage-specific regulation of antioxidant gene expression during metacyclogenesis and in infective/replicative forms of T

This suggests that ROS detoxification mediated by GpoA, as well as AhpD and TpxD, are important for the induction of antibiotic persistence under oxidative stress conditions, which is dependent of the imported glutathione (Fig

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